Product Name :
25-Hydroxyvitamin D3 (CAS 19356-17-3)
Synonym :
25-Hydroxyvitamin D3 is also known as Calcifediol.
Application :
25-Hydroxyvitamin D3 is a circulating metabolite of vitamin D, and the principal circulating form of vitamin D3.
CAS:
19356-17-3
Purity:
≥97%
Molecular Weight:
400.65
Formula :
C27H44O2
Physical state:
Solid
solubility :
Soluble in alcohol, acetone chloroform, ether, fixed oils, DMSO (~10 mg/ml), DMF (~10 mg/ml), 1:2 ethanol:PBS(pH7.2) (~0.3 mg/ml), chloroform, and methanol. Insoluble in water.
Shipping Condition :
Store at -20° C
Melting point:
105° C
SMILES:
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C
References:
:Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets.Formula of 4-Bromo-2-ethylpyridine | Bland, R.Phenylboronic acid Formula , et al.PMID:33666057 2004. J Steroid Biochem Mol Biol. 89-90: 121-5. PMID: 15225758Inhibition of prostate cancer-meditated osteoblastic bone lesions by the low-calcemic analog 1alpha-hydroxymethyl-16-ene-26,27-bishomo-25-hydroxy vitamin D3. | Peleg, S., et al. 2005. J Steroid Biochem Mol Biol. 97: 203-11. PMID: 1608128125-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells. | Ritter, CS., et al. 2006. Kidney Int. 70: 654-9. PMID: 1680754925-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand. | Lou, YR., et al. 2010. J Steroid Biochem Mol Biol. 118: 162-70. PMID: 19944755The ratio of serum 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation. | Wagner, D., et al. 2011. J Steroid Biochem Mol Biol. 126: 72-7. PMID: 21605672Role of 25-hydroxyvitamin D3 dose in determining rat 1,25-dihydroxyvitamin D3 production. | Vieth, R., et al. 1990. Am J Physiol. 258: E780-9. PMID: 2185661Supraphysiological 25-hydroxy vitamin D3 level at admission is associated with illness severity and mortality in critically ill patients. | Ralph, R., et al. 2015. J Bone Miner Metab. 33: 239-43. PMID: 24752822Tissue content of vitamin D3 and 25-hydroxy vitamin D3 in minipigs after cutaneous synthesis, supplementation and deprivation of vitamin D3. | Burild, A., et al. 2015. Steroids. 98: 72-9. PMID: 25725256Plasma concentrations of vitamin D3 and its metabolites in the rat as influenced by vitamin D3 or 25-hydroxyvitamin D3 intakes. | Shephard, RM. and Deluca, HF. 1980. Arch Biochem Biophys. 202: 43-53. PMID: 6249223Rat intestinal 25-hydroxyvitamin D3- and 1alpha,25-dihydroxyvitamin D3-24-hydroxylase. | Kumar, R., et al. 1978. J Biol Chem. 253: 3804-9. PMID: 649607Human bone cells in culture metabolize 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. | Howard, GA., et al. 1981. J Biol Chem. 256: 7738-40. PMID: 6973569Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. | Schwartz, GG., et al. 1998. Cancer Epidemiol Biomarkers Prev. 7: 391-5. PMID: 9610788