Product Name :
2-Chloro-N6-cyclopentyladenosine (CAS 37739-05-2)
Synonym :
CCPA
Application :
2-Chloro-N6-cyclopentyladenosine is a potent and selective Adenosine A1-R agonist
CAS:
37739-05-2
Purity:
Molecular Weight:
369.81
Formula :
C15H20ClN5O4
Physical state:
Solid
solubility :
Soluble in water (5 mM), DMSO (100 mM), 0.1N HCI (12 mg/ml), and methanol (20 mg/ml).
Shipping Condition :
Store at room temperature
Melting point:
258.03° C (Predicted)
SMILES:
C1CCC(C1)NC2=NC(=NC3=C2N=CN3C4C(C(C(O4)CO)O)O)Cl
References:
:Adenosine receptors and their ligands.4-bromopyrimidine hydrobromide manufacturer | Klotz, KN.t-BuXphos Palladacycle Gen. 4 uses 2000.PMID:33403946 Naunyn Schmiedebergs Arch Pharmacol. 362: 382-91. PMID: 11111832Release of atrial natriuretic factor induced by the A1 adenosine receptor agonist 2-chloro-N6-cyclopentyl-adenosine in the rat. | Massi, M., et al. 1992. Pharmacol Res. 25: 393-402. PMID: 1409251Highly selective A(1) -adenosine-agonist (2-chloro-N6-cyclopentyladenosine) and reduction of flap necrosis in adipocutaneous flaps in rats. | Dacho, AK., et al. 2012. Head Neck. 34: 1100-5. PMID: 22038887Adenosine A1 receptor activation attenuates lung ischemia-reperfusion injury. | Fernandez, LG., et al. 2013. J Thorac Cardiovasc Surg. 145: 1654-9. PMID: 23398646An adenosine A1 agonist 2-chloro-N6 cyclopentyladenosine inhibits the angiotensin II-induced cardiomyocyte hypertrophy through the calcineurin pathway. | Zhang, X., et al. 2014. Cardiology. 129: 153-62. PMID: 25277512Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats. | Fabera, P., et al. 2019. Front Pharmacol. 10: 656. PMID: 312584772-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. | Lohse, MJ., et al. 1988. Naunyn Schmiedebergs Arch Pharmacol. 337: 687-9. PMID: 3216901Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine. | Monopoli, A., et al. 1994. Arzneimittelforschung. 44: 1305-12. PMID: 7848348Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. | Concas, A., et al. 1993. J Pharmacol Exp Ther. 267: 844-51. PMID: 8246158Pretreatment with the adenosine A1 selective agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), causes a sustained limitation of infarct size in rabbits. | Tsuchida, A., et al. 1993. Cardiovasc Res. 27: 652-6. PMID: 8324800Measurement of guanine nucleotide-binding protein activation by A1 adenosine receptor agonists in bovine brain membranes: stimulation of guanosine-5′-O-(3-[35S]thio)triphosphate binding. | Lorenzen, A., et al. 1993. Mol Pharmacol. 44: 115-23. PMID: 83412671,3-Dipropyl-8-[2-(5,6-epoxy)norbornyl]xanthine, a potent, specific and selective A1 adenosine receptor antagonist in the guinea pig heart and brain and in DDT1MF-2 cells. | Belardinelli, L., et al. 1995. J Pharmacol Exp Ther. 275: 1167-76. PMID: 8531078Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase. | Kleppisch, T. and Nelson, MT. 1995. Proc Natl Acad Sci U S A. 92: 12441-5. PMID: 8618917Interaction of full and partial agonists of the A1 adenosine receptor with receptor/G protein complexes in rat brain membranes. | Lorenzen, A., et al. 1996. Mol Pharmacol. 49: 915-26. PMID: 8622642Pharmacological interactions between magnesium ion and adenosine on monoaminergic system in the central nervous system. | Okada, M. and Kaneko, S. 1998. Magnes Res. 11: 289-305. PMID: 9884987