Poxia/reoxygenation; IR: Ischemia/reperfusion; MAPK: Mitogen activated protein kinase; DAMPs: Damage-associated molecular patterns; NAC: N-acetyl cysteine; B-796: BIRB796 (p38MAPK inhibitor). Competing interests The authors declare no competing interests. Authors’ contributions MIA, DD, GB, JT contributed towards the design and style with the review. MIA, ME, CW, MH, HS, MHE, SS, KK, ME, SK, AS, CS, SV, RS performed the experiments and analysed the data. MIA compiled the data and prepared a very first manuscript draft, MIA, DD, JT contributed towards the creating with the manuscript. All authors read and accredited the final version of this manuscript. Acknowledgements This perform is supported by grants through the Jubil msfond der terreichischen Nationalbank (OeNB) project Nr. 13273, Austrian Science Basis (FWF), MCBO, ZFW011010-08, Austrian Federal Ministries BMVIT/ BMWFJ (through FFG) and also the Tiroler Zukunftsstiftung/Standortagentur Tirol (SAT), the terreichische Krebshilfe Tirol, the Larger Education Commission (HEC) Pakistan (assistance of MIA) and created doable through all the focused lab members.Formula of Pirfenidone The support by Mrs. Ruth Baldauf inside the preparation of the manuscript is drastically appreciated. We’re grateful to our colleagues Prof. W. C. Claycomb (Departments of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, LA) for the gift of HL-1 cells and Prof. Matthias Gaestel (Hannover, Germany) for giving us with MK2-deficient murine fibroblasts. We thank PD Florian Fuller MD, Uwe Hoff MD and Lyubov Chaykovska (Laboratoy of Duska Dragun) for technical support. PD Dr. Andrey Kozlov is acknowledged for his input in ROS measurement. Sincere thanks go to Prof. Raimund Margreiter, founder with the DSL and excellent supporter of its actions. We thank Profs. Wolfgang Doppler (Biocenter, IMU), and Alexander Rosenkranz (Graz Health care University, Austria) for his or her input as members of the thesis committee for MIA. Author details 1 Daniel Swarovski Exploration Laboratory, Division of Visceral, Transplantand Thoracic Surgical treatment, Innsbruck Health-related University (IMU), Innrain 66, 6020 Innsbruck, Austria. 2Molecular Biology Laboratory, Department of Visceral, Transplant and Thoracic Surgical treatment, Innsbruck Medical University (IMU), Sch fstra 41, Innsbruck 6020 Austria. 3Department of Anesthesiology and Critical Care Medication, Innsbruck Health care University (IMU), Anichstra 35, 6020 Innsbruck, Austria. 4Department of Pediatrics II, Innsbruck Medical University, Anichstra 35, 6020 Innsbruck, Austria. 5Soleiman Pathologie, Kugelanger 12a, 8060 Hall in Tirol, Austria. 6Department for Pathology, Innsbruck Health-related University, Innsbruck Health-related University (IMU), Anichstra 35, 6020 Innsbruck, Austria.Formula of 5-Chloro-4-methylpyridin-3-amine 7Clinic for Nephrology and Intensive Care Medication, Charit? Augustenburger Platz one, 13353 Berlin, Germany.PMID:33678074 8Current tackle: Reconstructive Transplantation Laboratory, Department of PlasticAshraf et al. Cell Communication and Signaling 2014, twelve:six http://biosignaling/content/12/1/Page 13 of21. Becatti M, Taddei N, Cecchi C, Nassi N, Nassi PA, Fiorillo C: SIRT1 modulates MAPK pathways in ischemic-reperfused cardiomyocytes. Cell Mol Daily life Sci 2012, 69:2245?260. 22. Cuadrado A, Nebreda A: Mechanisms and functions of p38 MAPK signalling. Biochem J 2010, 429:403?17. 23. Gorog DA, Jabr RI, Tanno M, Sarafraz N, Clark JE, Fisher SG, Cao XB, Bellahcene M, Dighe K, Kabir AM, et al: MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does.