Ke, M.; Ishiguro, K.; Plattner, F.; Uchida, T.; Isobe, T.; Hasegawa, M.; et al. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation web pages. J. Biol. Chem. 2013, 288, 7968?977.Int. J. Mol. Sci. 2014,101. Ferrer, I.; Blanco, R.; Carmona, M.; Puig, B. Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies. J. Neural Transm. 2001, 108, 1397?415. 102. Mohit, A.A.; Martin, J.H.; Miller, C.A. p493F12 kinase: A novel MAP kinase expressed in a subset of neurons in the human nervous method. Neuron 1995, 14, 67?8. 103. Zhu, X.3-Acetoxy-2-benzylpropanoic acid manufacturer ; Raina, A.K.; Rottkamp, C.A.; Aliev, G.; Perry, G.; Boux, H.; Smith, M.A. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer illness. J. Neurochem. 2001, 76, 435?41. 104. Knippschild, U.; Gocht, A.; Wolff, S.; Huber, N.; L ler, J.; St er, M. The casein kinase 1 family: Participation in numerous cellular processes in eukaryotes. Cell. Signal. 2005, 17, 675?89. 105. Singh, T.J.; Grundke-Iqbal, I.; Iqbal, K. Phosphorylation of tau protein by casein kinase-1 converts it to an abnormal Alzheimer-like state. J. Neurochem. 1995, 64, 1420?423. 106. Kuret, J.; Johnson, G.S.; Cha, D.; Christenson, E.R.; DeMaggio, A.J.; Hoekstra, M.F. Casein kinase 1 is tightly linked to paired-helical filaments isolated from Alzheimer illness brain. J. Neurochem. 1997, 69, 2506?515. 107. Li, G.; Yin, H.; Kuret, J. Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. J. Biol. Chem. 2004, 279, 15938?5945. 108. Schwab, C.; DeMaggio, A.J.; Ghoshal, N.; Binder, L.I.; Kuret, J.; McGeer, P.L. Casein kinase 1 delta is connected with pathological accumulation of tau in several neurodegenerative illnesses. Neurobiol. Aging 2000, 21, 503?ten. 109. Yasojima, K.; Kuret, J.; DeMaggio, A.J.; McGeer, E.; McGeer, P.L. Casein kinase 1 delta mRNA is upregulated in Alzheimer illness brain. Brain Res. 2000, 865, 116?20. 110. Ferrer, I.; Barrachina, M.; Puig, B.; Mart ez de Lagr , M.; Mart? E.; Avila, J.; Dierssen, M. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and associated transgenic models. Neurobiol. Dis. 2005, 20, 392?00. 111. Liu, F.; Liang, Z.; Wegiel, J.; Hwang, Y.W.; Iqbal, K.2-Amino-3-iodopyridine structure ; Grundke-Iqbal, I.PMID:33632712 ; Ramakrishna, N.; Gong, C.X. Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. FASEB J. 2008, 22, 3224?233. 112. Ryoo, S.R.; Jeong, H.K.; Radnaabazar, C.; Yoo, J.J.; Cho, H.J.; Lee, H.W.; Kim, I.S.; Cheon, Y.H.; Ahn, Y.S.; Chung, S.H.; et al. DYRK1A-mediated hyperphosphorylation of Tau. A functional hyperlink among Down syndrome and Alzheimer illness. J. Biol. Chem. 2007, 282, 34850?4857. 113. Wegiel, J.; Kaczmarski, W.; Barua, M.; Kuchna, I.; Nowicki, K.; Wang, K.C.; Wegiel, J.; Yang, S.M.; Frackowiak, J.; Mazur-Kolecka, B.; et al. Link involving DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. J. Neuropathol. Exp. Neurol. 2011, 70, 36?0. 114. Vingtdeux, V.; Davies, P.; Dickson, D.W.; Marambaud, P. AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer illness along with other tauopa.
