Product Name :
WSTF Recombinant Rabbit Monoclonal Antibody [JG36-32]
Predicted band size :
171 kDa
Observed band size :
171 kDa
Synonyms:
baz1b antibody BAZ1B_HUMAN antibody Bromodomain adjacent to zinc finger domain protein 1B antibody hWALP 2 antibody hWALP-2 antibody hWALP2 antibody transcription factor WSTF antibody Tyrosine-protein kinase BAZ1B antibody WALP-2 antibody WALP2 antibody 展开
Function :
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating ‘Tyr-142’ of histone H2AX (H2AXY142ph).425380-37-6 Order H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at ‘Tyr-142’, and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within Human WSTF aa 2-96 / 1,483.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, FC
Coupling :
unconjugated
Clone number:
JG36-32
RRID:
AB_3070831
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Fmoc-Bip(4,4′)-OH Order Aliquot store at -20℃.PMID:33576240 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
171 kDa
Positive control :
SiHa lysates, K562.