Product Name :
USP53 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
USP53 antibody KIAA1350 antibody Inactive ubiquitin carboxyl-terminal hydrolase 53 antibody Inactive ubiquitin-specific peptidase 53 antibody
Function :
Inactive ubiquitin carboxyl-terminal hydrolase 53 is a protein that in humans is encoded by the USP53 gene. Although USP53 is classified as a deubiquitinating enzyme based on sequence homology to other proteases from this group, it lacks a functionally essential histydine in the catalytic domaine and activity assays suggest that USP53 is catalytically inactive.(S)-3-Fluoropyrrolidine (hydrochloride) Chemscene Even though USP53 is devoid of catalytic activity, USP53 serves important physiological functions: mutations in Usp53 have been shown to cause progressive hearing loss in mice, as well as late-onset hearing loss and cholestasis in humans. USP53 localizes at cellular tight junctions and interacts with tight junction protein 2 (TJP2). Mutations in TJP2 have also been shown to cause hearing impairments and cholestasis.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
The antiserum was produced against synthesized peptide derived from human USP53. AA range:951-1000
Species reactivity:
Human
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.H-Val-Ala-OH Chemscene Aliquot store at -20℃ or -80℃.PMID:33453404 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
121 kDa
Positive control :
Brain, Fetal kidney,