Product Name :
Tim3 Mouse Monoclonal Antibody [1E3]
Predicted band size :
33 kDa
Observed band size :
42 kDa
Synonyms:
CD366 antibody FLJ14428 antibody HAVcr-2 antibody Havcr2 antibody HAVR2_HUMAN antibody Hepatitis A virus cellular receptor 2 antibody Kidney injury molecule 3 antibody KIM 3 antibody KIM3 antibody T cell immunoglobulin and mucin domain containing 3 antibody 展开
Function :
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion.1310481-47-0 Price The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse.368866-07-3 Formula
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein with Human Tim3 1-89 / 301.
Species reactivity:
Human
Verify application:
WB, IHC-P, IF-Cell, FC
Coupling :
unconjugated
Clone number:
1E3
RRID:
AB_3068747
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33480350 Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 33 kDa
Positive control :
A549 cell lysate, HepG2 cell lysate, HDLM-2 cell lysate, human colon cancer tissue, human tonsil tissue, 293T, Daudi.