Product Name :
Paxillin Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
FLJ16691 antibody FLJ23042 antibody Paired box protein Pax 1 antibody PAX 1 antibody PAX1 antibody PAXI_HUMAN antibody Paxillin alpha antibody Paxillin antibody PXN antibody PXN protein antibody
Function :
Paxillin is a focal adhesion phosphoprotein that is localized to the cytoskeleton.Minnelide Chemscene Phosphorylation of paxillin has been shown to occur in response to PDGF treatment, v-src transformation or cross-linking of integrins. FAK (focal adhesion kinase) and PYK2 have been shown to phosphorylate paxillin. FAK phosphorylates paxillin specifically on Tyr-118 in vitro. However, FAK phosphorylation does not seem to be required for the recruitment of paxillin to cell adhesion sites. Paxillin may play a role in signal transduction, regulation of cell morphology and the recruitment of structural and signaling molecules to focal adhesions. It has been shown that the amount of paxillin is reduced in mitotic cells by proteolytic downregulation and that paxillin is alternatively phosphorylated on serine rather than on tyrosine and serine during mitosis.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Amino acids 155-268 mapping within an internal region of paxillin of human origin.1-(2,2,2-Trifluoroethyl)piperazine site
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IP, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃
Storage buffer solution:
1.PMID:33632046 0 ml of PBS with
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
68kDa
Positive control :
293T, HISM, CCD-1064Sk.